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Global Health Snapshot - Neglected Tropical Diseases

Global Health Snapshot: Neglected Tropical Diseases


DengueA mosquito-borne viral infection causing a severe, flulike illness. Multiple infections may lead to the potentially lethal dengue hemorrhagic fever.

Symptoms: Flulike symptoms; severe form may result in shock caused by leaking blood vessels

Treatment: No specific treatment; supportive care only

Prevention: Insecticides and environmental management; personal protection

Location: Originally concentrated in Southeast Asia, it has spread rapidly to Central and South America over the past 20 years, as well as India, Australia and the Caribbean (most recently, Florida).

Incidence: 50 to 100 million dengue infections worldwide every year

Trending: 30-fold increase in incidence in last 50 years

Fact: Virus comprises four serotypes. After infection with one serotype, an infection by another increases risk of dengue hemorrhagic fever.

A Quadruple Threat: “A vaccine has to protect against all four serotypes. If it doesn’t,
you could actually set up a vaccinated population to have more severe disease [later]. That’s not something we see with other human diseases.”

Anna Durbin is collaborating on a clinical trial in Brazil that tests the safety of a tetravalent vaccine against dengue.


This forum is closed
  • Phyllis Sommer

    Chicago,Illinois 05/13/2011 11:21:40 AM

    Remember Chlamydia T. is a sexually transmitted disease and any prevention & teaching needs to include that fact. Condoms are number one prevention strategy. If people are warned about infertility as result of Chlamydia,they may be more amenable to condom use since fertility is highly valued in those countries.

  • Dr. B N Patnaik

    India 01/24/2012 02:23:35 AM

    I would like to know more about your C.trachomatis trail........I am preparing documents for clinical trailof Oral HPV vaccine in India .

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